Open AccessVALENCENE, A SESQUITERPENE EXHIBITS ANTILIPID PEROXIDATION AND ANTIOXIDANT EFFECTS IN THE PLASMA OF ISOPROTERENOLINDUCED MYOCARDIAL INFARCTED RATS
Author(s) -
S Shervin Prince,
V.M Berlin Grace
Publication year - 2022
Publication title -
ymer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.103
H-Index - 5
ISSN - 0044-0477
DOI - 10.37896/ymer21.04/05
Subject(s) - lipid peroxidation , antioxidant , myoglobin , chemistry , thiobarbituric acid , tbars , vitamin c , vitamin e , myocardial infarction , medicine , endocrinology , biochemistry
Aim: The present study was aimed to evaluate the effects of valencene, a sesquiterpene on plasma lipid peroxidation and antioxidants in isoproterenol-induced myocardial infarcted rats. Methods: Rats were induced myocardial infarction by isoproterenol (100 mg/kg body weight) on the 1st and 2nd day and then on the 4th-day valencene treatment was given to rats orally, daily, for 14 days. Results: Isoproterenol-induced myocardial rats showed an increase in the levels of serum myoglobin, plasma thiobarbituric acid reactive substances, and lipid hydroperoxides and a significant decrease in the levels of plasma non-enzymatic antioxidants such as reduced glutathione, vitamin- C, and vitamin-E. Oral treatment with valencene (12 mg/kg/body weight) daily for 14 days significantly reduced serum myoglobin and plasma lipid peroxidation and significantly increased non-enzymatic antioxidants. Conclusion: Thus this study reveals the anti-lipid peroxidation and antioxidant effects of valencene in isoproterenol-induced myocardial infarcted rats.