Open AccessIN VITRO CELL CYTOTOXICITY AND WOUND HEALING ACTIVITY OF TOPICAL FILM FORMING HYDROGEL OF PAPAIN UREA IN VERO CELLS
Author(s) -
Mrs. R Sruthi,
AUTHOR_ID
Publication year - 2022
Publication title -
ymer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.103
H-Index - 5
ISSN - 0044-0477
DOI - 10.37896/ymer21.02/34
Subject(s) - wound healing , papain , vero cell , debridement (dental) , cytotoxicity , in vitro , medicine , chronic wound , surgery , chemistry , pharmacology , enzyme , biochemistry
Wounds, whether acute or chronic, are one of the most common health problems worldwide, and medicative drugs are frequently used in wound healing. More research into wound treatment is being conducted at a rapid pace. For some wound types, enzymatic debridement of nonviable tissue remains the most effective debridement option. In theory, topical enzymes have been used in this therapy to remove necrotic tissue in the wound bed by digesting and dissolving the devitalized tissue. Papain, a plant-derived enzyme with a long history of clinical success, is one of these enzymes. The formulation of papain urea film forming gel is being used for wound repair. Vero cells were assessed in vitro for cell cytotoxicity and wound healing activity. When compared with the control, the results demonstrate significant healing activity and wound closure area. As a result of the findings of the study, the current formulation appears to be effective in healing wounds in in-vitro experiments