Open AccessFormulation, Development and Optimization of Ciclopirox Emulgel
Author(s) -
Swapeela,
AUTHOR_ID,
M.K.R. Konda,
Parijatha Bandigari,
Krishna Mohan Chinnala,
Balamallesh Kompelly,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID
Publication year - 2022
Publication title -
ymer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.103
H-Index - 5
ISSN - 0044-0477
DOI - 10.37896/ymer21.02/17
Subject(s) - emulsion , xanthan gum , chromatography , hydroxypropyl cellulose , chemistry , spreadability , carboxymethyl cellulose , diffusion , polymer , solubility , phase (matter) , chemical engineering , materials science , organic chemistry , sodium , rheology , composite material , thermodynamics , physics , food science , engineering
The present study was to formulate emulgel using Ciclopirox as drug of choice. Polymers like sodium carboxy methyl cellulose, carbopol 974P and xanthan gum were used as gelling agent in various proportions. Liquid paraffin was used as oil phase and a combination of Span 80 and Tween 80 were used as emulsifying agent. Both oil and aqueous phase were independently warmed to 75oC. At that point the aqueous phase was added to the oil phase with constant mixing until cooled to room temperature. The gel bases were prepared by scattering diverse concentrations of polymers in refined water. The obtained emulsion was mixed with the gel with gentle stirring to obtain the emulgel. Various formulations were prepared by changing the gelling agent and their concentration. The prepared emulgels were evaluated for physical appearance, pH, spreadability co-efficient, physical stability, drug content and in-vitro drug release. All the formulations were physically stable with the pH values within the range and have shown good spreadability coefficient. In-vitro diffusion studies were carried out using pH 7.4 phosphate buffer. Formulation F6 was found to be the optimized formulation and it has shown best results with zero order release kinetics and diffusion mechanism.