Open AccessFormulation and Physicochemical Evaluation of Azathioprine Loaded Ethyl cellulose Microspheres using Solvent Evaporation Technique
Author(s) -
A Kokilavani,
AUTHOR_ID,
P Jeyaprabha,
V. Ganesan,
R. Senthamarai,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID
Publication year - 2022
Publication title -
ymer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.103
H-Index - 5
ISSN - 0044-0477
DOI - 10.37896/ymer21.01/51
Subject(s) - ethyl cellulose , microsphere , particle size , solvent , materials science , chemical engineering , cellulose , polymer , fourier transform infrared spectroscopy , evaporation , micrometer , nuclear chemistry , chemistry , organic chemistry , composite material , engineering , physics , optics , thermodynamics
The present study is associated with Formulation and physicochemical evaluation of azathioprine loaded Ethyl cellulose microspheres. Azathioprine is an immunosuppressant drug which used in the treatment of Rheumatoid arthritis. In this study Azathioprine microspheres were prepared by solvent evaporation technique by using Ethyl cellulose as polymer. Prepared microspheres were evaluated by particle size analysis, UV spectroscopy, SEM Analysis, FT-IR spectroscopy and encapsulation efficiency. Particle size of prepared microspheres was ranges from 10 to 50 micrometer. SEM pictures of microspheres conforms the perfect spherical particles and uniform smooth surface. FT-IR spectroscopy reveals there is no interaction between drug and polymer while formulating the microspheres. The percentage yield of microspheres was 91.42%. Encapsulation efficiency was found to be 48%. The formulation plays an important role in controlled release as well as prolonged release in the treatment of inflammation.