Open AccessPhotodynamic therapy of penile leukoplakia: a case report
Author(s) -
Nasrulla Shanazarov,
B. G. Kassymov,
Timur M. Muratov,
С. В. Зинченко
Publication year - 2022
Publication title -
lazernaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2686-8644
pISSN - 2071-8004
DOI - 10.37895/2071-8004-2021-25-3-29-33
Subject(s) - photosensitizer , photodynamic therapy , irradiation , medicine , laser , oral leukoplakia , nuclear medicine , leukoplakia , optics , chemistry , cancer , photochemistry , physics , organic chemistry , nuclear physics
Purpose : to describe a clinical case of successful application of photodynamic therapy (PDT) in a patient with leukoplakia of the glans penis skin. Material and methods . For PDT, chlorin-type photosensitizer “Photolon” was used. The photosensitizer (lyophilized powder) was diluted in 200.0 ml of 0.9 % sodium chloride solution, administered intravenously at dosage 1.5 mg/kg of body weight. After 2.5 hours, intravenous laser blood irradiation was performed with “Lakhta-Milon” laser device (output power – 100 mW, exposure – 30 minutes). Before PDT, uorescence diagnostics in ultraviolet light with wavelength 395–405 nm was performed. PDT technique was single-eld irradiation with output power 1800 mW (1.8 W), irradiation energy density – 150 J/cm 2 . Power density of laser light was 200 mW/cm 2 . Exposure time – 14 min. Results . After treatment, complete regression of the pathological focus and regeneration of healthy tissue were marked (one month). Conclusion. PDT in a patient with leukoplakia of glans penis is an effective and safe curative technique.