Open AccessSINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN 3,5 BIS((E)-METOKSI BENZILIDEN)-1-(2-ETIL ASETAT)-PIPERIDIN-4-ON
Author(s) -
Siti Aisyah,
Adel Zamri,
Hilwan Yuda Teruna
Publication year - 2018
Publication title -
photon: jurnal sain dan kesehatan/photon : jurnal sain dan kesehatan
Language(s) - English
Resource type - Journals
eISSN - 2579-5953
pISSN - 2087-393X
DOI - 10.37859/jp.v9i1.1075
Subject(s) - chemistry , curcumin , piperidine , benzaldehyde , nuclear chemistry , ethyl acetate , yield (engineering) , organic chemistry , chromatography , stereochemistry , materials science , biochemistry , metallurgy , catalysis
Curcumin analogs are secondary metabolites and belong to the phenolic group. These compounds have biological activities, such as anti-inflammatory, anticancer and antioxidant. This studies has successfully synthesized 3,5-bis ((E)-metoxy benzylidene) -1-(- 2-ethyl acetate) piperidine 4-one analog compound from 4-piperidone with 4-methoxy benzaldehyde by using reflux method. Compounds obtained in the form of yellow solids with yield 83.01%. The melting point was measured, identified by TLC then elucidated with UV-Vis, FT-IR, LC-MS, 1H NMR obtained results showed that the curcumin compound had a structure in accordance with the target molecule. The toxicity test using the BSLT method showed that the two compounds had LC50 values = 1.061μg / mL.