Open AccessTHE REPORTED SUCCESSFUL BABY DELIVERY AFTER PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDIES (PGT-A) BY MEANS OF NEXT GENERATION SEQUENCING (NGS)
Author(s) -
N.P. Nigmatova,
B.Zh. Abdilmanova,
V. Schigolev
Publication year - 2020
Publication title -
reproduktivnaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2960-1665
pISSN - 2303-9949
DOI - 10.37800/rm2020-1-10
Subject(s) - blastocyst , genetic testing , blastocyst transfer , gestation , gynecology , karyotype , aneuploidy , obstetrics , medicine , biology , pregnancy , chromosome , genetics , embryo , embryogenesis , gene
The aim of this case report is to demonstrate a successful delivery of a baby after transfer of a blastocyst tested for aneuplodies by means of NGS. A woman aged 35 having two miscarriages decided for ICSI program with PGT-A analysis. Six eggs were fertilized out of 9 metaphase II oocytes. Five good quality blastocysts were submitted for genetic screening using 24-chromosome next generation sequencing (NGS). Two blastocysts were diagnosed as euploid and recommended for transfer. One euploid blastocyst was thawed and transferred to the patient’s uterus lining. Successful pregnancy was confirmed at 7 weeks of gestation with heartbeat. Successful delivery was achieved by Caesarean section at 38-39 weeks of gestation. Karyotyping demonstrated healthy genetic constitution of a baby. This case demonstrates a good evidence and potential of a transport scheme collaboration between IVF and genetic laboratories.