Open AccessPolymorphisms of Vascular Endothelial Growth Factor -2578C/A rs699947 are Risk Factors for Diabetic Retinopathy in Type-2 Diabetes Mellitus Patients in Bali, Indonesia
Author(s) -
Audrey Rachel Wijaya,
I Wayan Surudarma,
Desak Made Wihandani,
I Wayan Ardyan Sudharta Putra
Publication year - 2021
Publication title -
biomedicine
Language(s) - English
Resource type - Journals
eISSN - 2211-8039
pISSN - 2211-8020
DOI - 10.37796/2211-8039.1170
Subject(s) - medicine , diabetic retinopathy , type 2 diabetes mellitus , diabetes mellitus , vascular endothelial growth factor , risk factor , retinopathy , growth factor , ophthalmology , vegf receptors , endocrinology , receptor
Diabetic retinopathy (DR) is one of the complications in diabetes mellitus (DM) which caused by microvascular-damage in the retina due to long termmetabolic changes in diabetes. To date, there has been much research targeted on the determinant of genetic identification in DR patients. In DR, Vascular Endothelial Growth Factor (VEGF) gene is accountable for breaking down the blood-retinal barrier and implicated in the role of neovascularization. It is thought that the polymorphism of VEGF -2578C/A (rs699947) contributed to the development of diabetic retinopathy in type 2 DM.