Open AccessComparison between C4d immunohistochemical staining and other clinical- hisopathological findings in IgA nephropathy
Author(s) -
Hossein Samadi Kafil,
Hamed Sharifi
Publication year - 2021
Publication title -
biomedicine
Language(s) - English
Resource type - Journals
eISSN - 2211-8039
pISSN - 2211-8020
DOI - 10.37796/2211-8039.1118
Subject(s) - medicine , immunohistochemistry , nephropathy , proteinuria , pathology , biopsy , renal biopsy , biomarker , kidney disease , gastroenterology , kidney , diabetes mellitus , endocrinology , biochemistry , chemistry
IgAN occurs following abnormal IgA deposition in the glomerular mesangial regions. It is the most common primary glomerular disease and one of the causes of ESRD, so it is necessary to identify clinical and histopathological findings that predict progression to ESRD. In the physiopathology of this disease, C 4 d causes serious renal injuries and should be counted as a significant prognostic factor too. This study examined C 4 d biomarker and compare it with findings affecting prognosis, to determine the predictive value of C 4 d in progression to ESRD in IgAN.