Open AccessINFLUENCE OF FAT CELLS ON PATHOGENETIC LINKS OF INFLAMMATION MECHANISMS IN PATIENTS WITH PURIFIC WOUNDS THAT DO NOT HEAL FOR A LONG TIME
Author(s) -
K. A. Goltsev,
Ігор Андрійович Криворучко,
A. M. Goltsev,
K. Yu. Parkhomenko,
V. M. Cheverda
Publication year - 2020
Publication title -
harkìvsʹka hìrurgìčna škola
Language(s) - English
Resource type - Journals
ISSN - 2308-7005
DOI - 10.37699/2308-7005.4.2020.08
Subject(s) - chymase , wound healing , inflammation , homeostasis , tryptase , medicine , bioinformatics , intensive care medicine , biology , immunology , mast cell
Summary. The purpose of the study is - study of sources of domestic and world literature on the problem of pathophysiological disorders of local homeostasis involving mast cells (МC) in purulent long-term non-healing wounds (PLTNHW).
Research tasks — according to the literature, to identify the features of the course of the wound process and the possibility of regulating local homeostasis with the participation of MC in patients with PLTNHW.
Conclusions. Thus, considerable progress has been made so far in understanding the molecular mechanisms of the basic phases of the normal and complicated wound process. A new step towards effective solution of the socially significant problem of surgical treatment of extensive wound defects in PLTNHW is further study of the processes of direct intercellular interaction and selection of tryptase and chymase MC as indicators of the state of the healing process and a target for pathogenetic action.