COAGULOGRAM INDICES IN PATIENTS WITH DEEP VEIN TROMBOSIS, DEPENDING ON THE METHOD OF TREATMENT

Summary. Despite a satisfactory number of research which dedicated on coagulogram changes in patients with DVT, they are rarely used in clinical practice for the diagnosis of thrombosis, more often for the correction of anticoagulant therapy. The aim of research. Estimate the changes of coagulogram indices in patients with deep vein thrombosis, depending on the type of treatment performed. Materials and methods. Has been performed the quantitative estimation of coagulogram indices in 721 patients with deep vein thrombosis. Depending on the treatment method, the patients were divided into two groups: І – 382 (53 %) patients, which performed the surgical treatment with the following prescription the anticoagulant therapy; ІІ – 339 (47 %) patients, which performed only the anticoagulant therapy. Results. Has been observed more expression of hypocoagulation in patients of I group for the essesment the most of the coagulogram indices: the level of D-dimer was 14.1 % lower than in II group, the average concentration of thrombocyte was 7.8 %, the prothrombin index was 7.1 %, the international normalized ratio by 3.8 %, the level of hematocrit by 2.4 %, platelet count by 1.9 % lower than in patients ІІ group. More expression the prolongation of activated thromboplastin time, activated recalcification time and prothrombin time for 37.9 %, 10.6 % and 4.8 %, respectively, was observed in I group compared with the patients II group. At the same time, the level of fibrinogen in the I group was 9.1 % higher compared with the patients II group. Conclusions. Hypocoagulation changes of haemostasis in patients which performed the surgical treatment for deep vein thrombosis, compared to patients with isolated anticoagulant therapy, suggest that mechanical removal of thrombotic masses promotes faster normalization of indices hemostasis.