Open AccessDiabetic foot ulcers treatment with silver nanoparticles
Author(s) -
César Alejandro Almonaci Hernández,
Isis Marion Cabrera Torres,
Rosangela López-Acevedo,
Karla Juárez-Moreno,
Martin E. Castañeda-Juárez,
Horacio Almanza-Reyes,
Alexey Pestryakov,
Nina Bogdanchikova
Publication year - 2019
Publication title -
revista de ciencias tecnológicas
Language(s) - English
Resource type - Journals
ISSN - 2594-1925
DOI - 10.37636/recit.v212025
Subject(s) - diabetic foot , medicine , granulation tissue , silver nanoparticle , antimicrobial , amputation , lesion , fibrin , antibiotics , diabetic foot ulcer , edema , debridement (dental) , diabetes mellitus , surgery , dermatology , gastroenterology , wound healing , microbiology and biotechnology , materials science , nanoparticle , immunology , endocrinology , nanotechnology , biology
Diabetic foot ulcers are highly susceptible to microbial infections and are the leading cause of lower limb hospitalization and amputation in diabetic patients. Due to their antimicrobial and anti-inflammatory properties, silver nanoparticles (AgNPs) are the most widely used nanomaterial in biomedicine. Herein, we present the usage of AgNPs for the treatment of diabetic foot ulcers with a stage II in Wagner classification. In addition to conventional antibiotic treatment, the ulcers were treated with topical administration of AgNPs at a concentration of 1.2 mg/ml of metallic silver. The results showed a significant improvement in the evolution of the ulcers, where the edges of the lesion were effectively approached, granulation tissue being observed, edema decreased and fibrin plaques. These results form the basis for further studies on the use of AgNPs for the treatment of chronic ulcers of different origins.