Open AccessDesign, synthesis and investigation of water-soluble hemi-indigo photoswitches for bioapplications
Author(s) -
Daria V. Berdnikova
Publication year - 2019
Publication title -
beilstein journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 66
eISSN - 2195-951X
pISSN - 1860-5397
DOI - 10.3762/bjoc.15.275
Subject(s) - indigo , chemistry , biomolecule , fluorescence , aqueous solution , combinatorial chemistry , derivative (finance) , nanotechnology , organic chemistry , biochemistry , materials science , optics , physics , financial economics , economics
A series of hemi-indigo derivatives was synthesized and their photoswitching properties in aqueous medium were studied. The dimethoxy hemi-indigo derivative with the best photochromic performance in water was identified as a promising platform for the development of photoswitchable binders for biomolecules. The synthetic approach towards the introduction of the alkylamino pendant to the dimethoxy hemi-indigo core was developed that allowed to obtain an RNA-binding hemi-indigo derivative with photoswitchable fluorescent properties.