Open AccessPerspectives of targeted therapy for nonspecific back pain: a review of recent publications
Author(s) -
Т. М. Маневич,
Э. А. Мхитарян,
А. В. Наумов
Publication year - 2021
Publication title -
rossijskij žurnal geriatričeskoj mediciny
Language(s) - English
Resource type - Journals
eISSN - 2686-8709
pISSN - 2686-8636
DOI - 10.37586/2686-8636-3-2021-313-318
Subject(s) - medicine , chronic pain , pharmacotherapy , back pain , quality of life (healthcare) , physical therapy , epidemiology , pain syndrome , intensive care medicine , bioinformatics , alternative medicine , pathology , nursing , biology
The high incidence of back pain in older people, its effect on quality and duration of life, and insufficient effectiveness of existing treatment methods determine the need to search for methods of back pain treatment that will reduce inflammatory and degenerative changes and the pain syndrome itself. The review analyzes the epidemiology, pathogenesis, current methods of pharmacotherapy for back pain, the role of genetic changes and biomarkers of chronic pain, discusses current prospects for the use of targeted therapy for the treatment of chronic nonspecific back pain based on pathogenetic mechanisms (genetic changes, aseptic inflammation, immune disorders, disorders of chondrogenesis, etc.).