Open AccessAging bone
Author(s) -
Н. В. Браилова,
В. А. Кузнецова,
Е. Н. Дудинская,
О. Н. Ткачева
Publication year - 2020
Publication title -
rossijskij žurnal geriatričeskoj mediciny
Language(s) - English
Resource type - Journals
eISSN - 2686-8709
pISSN - 2686-8636
DOI - 10.37586/2686-8636-2-2020-147-153
Subject(s) - osteoporosis , adipogenesis , bone mineral , somatic cell , bone tissue , bone formation , medicine , bioinformatics , endocrinology , gene , biology , anatomy , genetics , adipose tissue
This review article deals with the topic of changes in bone tissue in the process of aging of the body. Adipogenesis and osteogenesis are affected at the molecular level, proteins and genes are described, in which somatic mutation can occur during the aging process, resulting in both minor changes and an active loss of bone mineral density. The factors that affect the change in bone mineral density mainly in the elderly, and existing drugs that can slow down osteoporosis are listed. Knowledge of the cellular and molecular mechanisms underlying the aging of bone tissue will contribute to the creation of targeted therapy for osteoporosis, which slows down bone aging and prevents falls and fractures in the elderly people.