Effects Of F-18 On KCL And Phenylephrine - Induced Contractions Of Rat Aorta | Zendy

Abdisalim A. Zaripov | Zendy; Adilbay Esimbetov | Zendy; Pulat B. Usmanov | Zendy; Durdona Shokirova | Zendy; Sherzod Zhurakulov | Zendy

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Effects Of F-18 On KCL And Phenylephrine - Induced Contractions Of Rat Aorta

Author(s) -

Abdisalim A. Zaripov,

Adilbay Esimbetov,

Pulat B. Usmanov,

Durdona Shokirova,

Sherzod Zhurakulov

Publication year - 2021

Publication title -

the american journal of medical sciences and pharmaceutical research

Language(s) - English

Resource type - Journals

ISSN - 2689-1026

DOI - 10.37547/tajmspr/volume03issue06-16

Subject(s) - isometric exercise , phenylephrine , contraction (grammar) , aorta , alkaloid , chemistry , smooth muscle , mechanism of action , medicine , vascular smooth muscle , biophysics , anatomy , stereochemistry , biology , biochemistry , in vitro , blood pressure

The mechanism of action of the alkaloid 1-(2´-bromine-4´,5´-dimethoxyphenyl) - 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) on the functional activity of smooth muscle cells of the rat aorta was studied. Isometric contraction activity was recorded using a Grass FT – 03 (Grass Instrument, USA) mechanotron. The relaxant effect of the F-18 alkaloid was found to be associated with blockade of Ca2 + (IP3R) channels in the SR, along with voltage- dependent and receptor-operated Ca2+channels in the aorta smooth muscle cell plasmalemma.

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