Open AccessEffects Of F-18 On KCL And Phenylephrine - Induced Contractions Of Rat Aorta
Author(s) -
Abdisalim A. Zaripov,
Adilbay T. Esimbetov,
П. Б. Усманов,
Durdona Shokirova,
Sherzod Zhurakulov
Publication year - 2021
Publication title -
the american journal of medical sciences and pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 2689-1026
DOI - 10.37547/tajmspr/volume03issue06-16
Subject(s) - isometric exercise , phenylephrine , contraction (grammar) , alkaloid , aorta , chemistry , smooth muscle , mechanism of action , medicine , biophysics , anatomy , stereochemistry , biology , biochemistry , blood pressure , in vitro
The mechanism of action of the alkaloid 1-(2´-bromine-4´,5´-dimethoxyphenyl) - 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) on the functional activity of smooth muscle cells of the rat aorta was studied. Isometric contraction activity was recorded using a Grass FT – 03 (Grass Instrument, USA) mechanotron. The relaxant effect of the F-18 alkaloid was found to be associated with blockade of Ca2 + (IP3R) channels in the SR, along with voltage- dependent and receptor-operated Ca2+channels in the aorta smooth muscle cell plasmalemma.