Open AccessStudy Of The Neuroprotective Properties Of Biologically Active Compounds
Author(s) -
Nozim N. Кhoshimov,
Azizov V.G.,
A. R. Abduboqiyev,
Rakhimov R.N.
Publication year - 2021
Publication title -
the american journal of medical sciences and pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 2689-1026
DOI - 10.37547/tajmspr/volume03issue05-01
Subject(s) - glutamate receptor , nmda receptor , biophysics , chemistry , binding site , calcium , neuroprotection , intracellular , biochemistry , receptor , conductance , pharmacology , biology , mathematics , organic chemistry , combinatorics
The works show that, using fluorescent probes, it was used to study the effect of PC-8 on changes in the dynamics of the intracellular Ca2+ content in synaptosomes of the rat brain, depending on the site of the binding of glutamate on calcium channels by a specific mediator with glutamate. To measure the amount of cytosolic Ca2+ synaptosomes, we calculated using the Grinkevich equation. It has been shown that polyphenol PC-8 binds to the glutamate-binding site of NMDA receptors, so that the conductance for Ca2+ ions is reduced through a channel blocking the effect of polyphenol PC-8 can be explained. due to its binding to the competing action of the site, the binding of glutamate to NMDA receptors.