Open AccessLaboratory And Molecular-Genetic Markers Of The Progression Of Non-Alcoholic Fatty Liver Disease (literature review and own data)
Author(s) -
Hamrayev A.A.,
Yuldasheva D.H.
Publication year - 2021
Publication title -
the american journal of medical sciences and pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 2689-1026
DOI - 10.37547/tajmspr/volume03issue03-11
Subject(s) - steatohepatitis , fatty liver , hepatology , disease , hepatocellular carcinoma , medicine , fibrosis , gastroenterology , bioinformatics , biology
Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases in hepatology. First of all, this is associated with a high risk of progression of NAFLD with the development of non-alcoholic steatohepatitis (NASH), liver failure, and hepatocellular carcinoma. Epidemiological and genetic studies have shown the relationship between the morphological stage of NAFLD and hereditary factors. The article provides a review of the literature on the cytokines, MBOAT7 and GCKR genes. Also, a variant of the MBOAT7 and GCKR gene is associated with a high risk of fibrosis in patients with NAFLD and elevated serum triglyceride levels.