Open AccessImpact Of Defensive Covering Of Anti-Inflamatory Medicine Tablets With Acrylatemethacrylate Copolymers On Tablet Crumbling Times And Disintegration Rates
Author(s) -
Boutaiba Farida
Publication year - 2020
Publication title -
the american journal of medical sciences and pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 2689-1026
DOI - 10.37547/tajmspr.v2i06.372
Subject(s) - copolymer , materials science , polymer , chemistry , composite material
Tablets of headache medicine (a dampness degradable medication) have been film covered with two undifferentiated from Eudragit RL and RS copolymers assigned here as An and B which vary just in their cation content in the proportion 2:1 (A:B). An, is in this manner more hydrophilic than B. The tablets were film covered with ethanol arrangements of these two polymers. Film covering with either An or B fundamentally decreased the dampness take-up possibilities of the tablets however caused an expansion in the breaking down occasions of the tablets and hindered disintegration rates. The mean deterioration times were 0.5±0.1 min (uncoated tablets), 16±2.5 min (tablets covered with An) and 115±3.6 min (tablets covered with B). The relating disintegration rates % h - 1 were 28.3 for uncoated, 16.6, covered with An and 14.8, covered with B, separately. Subsequently, covering with polymer B impressively impeded the crumbling and disintegration properties of the tablets.