Open AccessBiochemical and Haematological Effects and Histopathological Changes caused by Moringa oleifera on Albino Rats
Author(s) -
Elmuaiz Gasmalbari,
Hatil Hashim EL-Kamali,
Osama Sharafeldin Abbadi
Publication year - 2020
Publication title -
chinese journal of medical research
Language(s) - English
Resource type - Journals
eISSN - 2663-8053
pISSN - 2618-091X
DOI - 10.37515/cjmr.091x.3306
Subject(s) - moringa , albumin , creatinine , histology , white blood cell , hemoglobin , blood lipids , cholesterol , kidney , medicine , pharmacology , traditional medicine
Background: Of the plant family Moringaceae, Moringa oleifera is the most popular. It draws researchers’ attention by its nutritional and phytochemical properties. The potential effects of this plant are still to be explored. This study aimed to evaluate the effect of Moringa olifiera in the blood glucose, serum lipids, hemoglobin, hematologic values of blood cells, and the possible organ toxicity of this plant by measuring liver and kidney functions and histology. Materials and method: Moringa olifiera leaves were pounded to powder using a pestle. 100mg for each kilogram of bodyweight (mg/kg/bw) were weighted for each rat. Sera for blood glucose, lipid profile, blood parameters, and histology slides for liver and kidneys were prepared and studied after the above dose administration-orally, for three weeks. Results: Administration of aqueous Moringa leaves100mg/kg/bw to rats for 21days caused a significant decrease in the triglycerides level, plasma cholesterol, blood glucose, platelets count, plasma proteins and albumin. There was a significant increase in the body weight. White blood cells (WBCs) and packed cell volume (PCV) increased significantly, but the changes in Red blood cells (RBCs), haemoglobin level, blood urea and creatinine were not statistically significant. Features of tissue injury were seen in the liver and renal histology slides. Conclusion: The effects of Moringa olifiera in albino rats in this study agrees with most of the previous researches, but contradicts the literature with regards to the cholesterol and renal function results.