Open AccessOptimization of statin use: genetic factors and therapeutic drug monitoring
Author(s) -
Р. Е. Казаков,
А. Б. Прокофьев
Publication year - 2020
Publication title -
farmakogenetika i farmakogenomika
Language(s) - English
Resource type - Journals
eISSN - 2686-8849
pISSN - 2588-0527
DOI - 10.37489/2588-0527-2020-1-11-18
Subject(s) - slco1b1 , statin , medical prescription , therapeutic drug monitoring , medicine , drug , pharmacogenetics , intensive care medicine , pharmacology , bioinformatics , biology , genetics , gene , genotype
The article is devoted to the description of the global experience of personalized prescription of statins. The prerequisites for including the genetic factor, the carriage of the c.521C allele of the gene SLCO1B1, into the statin prescribing algorithm are stated. Also set out the reasons that complicate the introduction of therapeutic drug monitoring of statins into clinical practice are described.