Open AccessPossibilities for the use of hydroxychloroquine for pre- and postexposure prophylaxis of SARS-CoV-2 infection among exposed contacts and healthcare personnel
Author(s) -
В. А. Отделенов,
А. В. Крюков,
Д. А. Сычёв
Publication year - 2020
Publication title -
kačestvennaâ kliničeskaâ praktika
Language(s) - English
Resource type - Journals
eISSN - 2618-8473
pISSN - 2588-0519
DOI - 10.37489/2588-0519-2020-s4-81-86
Subject(s) - hydroxychloroquine , medicine , christian ministry , covid-19 , pre exposure prophylaxis , health care , human immunodeficiency virus (hiv) , intensive care medicine , emergency medicine , virology , disease , infectious disease (medical specialty) , philosophy , theology , syphilis , men who have sex with men , economics , economic growth
There currently exists no published robust data which would confirm effectiveness and safety of hydroxychloroquine in pre- and postexposure prophylaxis of SARS-CoV-2 infection. Taking into account in vitro data, which indicates inhibitory activity of hydroxychloroquine against SARS-CoV-2, and interim guidelines by the Ministry of Health of the Russian Federation, hydroxychloroquine can be considered as postexposure prophylaxis among healthcare personnel who have been in contact with patients with laboratory confirmed SARS-CoV-2, provided no contraindications and significant drug interactions are present. Safety monitoring should be performed before prescribing and during the course of treatment (ECG, total blood count and blood biochemistry, ophthalmologist evaluation before long-term treatment).