Open AccessAbsolute bioavailability of a substance with cardioprotective activity (ALM-802) in rats
Author(s) -
Г. Б. Колыванов,
П. О. Бочков,
А. А. Литвин,
Р. В. Шевченко,
Анна Леонидовна Подолько,
В. П. Жердев
Publication year - 2022
Publication title -
farmakokinetika i farmakodinamika
Language(s) - English
Resource type - Journals
eISSN - 2686-8830
pISSN - 2587-7836
DOI - 10.37489/2587-7836-2021-2-31-35
Subject(s) - bioavailability , pharmacology , pharmacokinetics , oral administration , medicine , chemistry
The pharmacokinetics of a new potential cardioprotective agent ALM-802 was studied in rats after single intravenous and intragastric administration at doses of 10 and 100 mg/kg, respectively. The absolute bioavailability was 4.45 %, which indicates the potential for the development of a dosage form for oral administration