Open AccessEffect of nerve growth factor dimeric mimetic GK-2 on microcirculation in skeletal muscle on the hind limb ischemia model in rats
Author(s) -
И. Б. Цорин,
А. О. Ефимова,
E. S. Pekeldina,
М. Б. Вититнова,
С. А. Крыжановский
Publication year - 2021
Publication title -
farmakokinetika i farmakodinamika
Language(s) - English
Resource type - Journals
eISSN - 2686-8830
pISSN - 2587-7836
DOI - 10.37489/2587-7836-2020-4-9-13
Subject(s) - hindlimb , microcirculation , ischemia , medicine , skeletal muscle , perfusion , calf muscle , femoral artery , anatomy , anesthesia , endocrinology
The purpose of the study . In experiments on a hind limb ischemia model in rats, the effect of the TrkA-receptor agonist of the NGF 4th loop dimeric dipeptide mimetic compound GK-2 has been studied on microcirculation in ischemic skeletal muscle. Methods . the Hind limb ischemia was caused in white male mongrel rats by the femoral artery resection. The compound GK-2 was administered intravenously (1 mg/kg/day during 14 days). Microcirculation parameters were recorded using a computer laser analyzer "LAKK-OP2". Registration was carried out simultaneously in the intact and operated limb before the operation, 1 and 14 days after it. Results . In the conditions of the hind limb ischemia model, it was shown that the compound GK-2 almost completely restored the perfusion index and its variation coefficient in the ischemic muscle to the intact contralateral limb level by the 14th day after surgery. Conclusion . It can be assumed that the anti-ischemic effect of the compound GK-2 is associated with the restoration of microcirculation as a result of increased neoangiogenesis.