Open AccessStudy the subchronic toxicity of the drug Dantinorm Baby
Author(s) -
А. В. Сорокина,
С. В. Алексеева,
И. А. Мирошкина,
К. С. Качалов,
A. D. Zaharov,
Yu. V. Alekseev,
A. S. Lapizkaya
Publication year - 2021
Publication title -
farmakokinetika i farmakodinamika
Language(s) - English
Resource type - Journals
eISSN - 2686-8830
pISSN - 2587-7836
DOI - 10.37489/2587-7836-2020-3-52-60
Subject(s) - drug , dose , medicine , toxicity , therapeutic index , pharmacology , therapeutic effect , drug toxicity
Presents results of a study of subchronic toxicity of homeopathic drug Dantinorm Baby in finished dosage form. The drug in the form of a ready solution was administered daily orally for one month to outbred rats Infanta and chinchilla rabbits at a dose of 0.3 ml/kg, corresponding to the therapeutic, and 3 ml/kg, exceeding the therapeutic dose 10 times. Clinical, laboratory and histopathological studies performed in accordance with the General Protocol, showed no toxic effects of homeopathic preparation of Dantinorm Baby. The totality of the obtained data of the subchronic experiment indicates that there are no obstacles to the clinical study of the drug Dantinorm Baby in the range of therapeutic dosages.