Open AccessAntidepressant-like activity of the dipeptide mimetic of brain-derived neurotrophic factor GSB-106 in Porsolt test after intraperitoneal sub-chronically and chronically treatment in mice
Author(s) -
Анна Вадимовна Таллерова,
P. Yu. Povarnina,
С В Минаев,
Татьяна Александровна Гудашева,
С. Б. Середенин
Publication year - 2020
Publication title -
farmakokinetika i farmakodinamika
Language(s) - English
Resource type - Journals
eISSN - 2686-8830
pISSN - 2587-7836
DOI - 10.37489/2587-7836-2019-4-24-27
Subject(s) - intraperitoneal injection , antidepressant , medicine , pharmacology , neurotrophic factors , behavioural despair test , brain derived neurotrophic factor , anesthesia , hippocampus , receptor
The present work was to study the GSB-106 effect on the immobility behavior of mice Balb/c in the Porsolt test. GSB-106 was administered sub-chronically and chronically intraperitoneal in dose 1 mg/kg. GSB-106 administration significantly decreased immobility time in mice by 1.2 times after 4 days, by 1.3 times after 14 days and 1.2 times after 21 days’ injections. Thus, the dependence of the GSB-106 effect-time administration in the Porsolt test was not established.