Open AccessPathogenetic Role and Possibilities for Correction of Gut Microbiota Disorders in Urinary Tract Infections
Author(s) -
Н В Стуров,
С. В. Попов,
В. А. Жуков
Publication year - 2021
Publication title -
antibiotiki i himioterapiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.112
H-Index - 11
ISSN - 0235-2990
DOI - 10.37489/0235-2990-2021-66-7-8-100-108
Subject(s) - gut flora , urinary system , colonisation resistance , fecal bacteriotherapy , disease , immunology , biology , gastrointestinal tract , antimicrobial , colonization , microbiology and biotechnology , pathogenic bacteria , bacteria , medicine , antibiotics , genetics , clostridium difficile
The article presents current data on the role of gut microbiota in the development of urinary tract infections. The main pathogenetic mechanisms contributing to the chronic recurrent course of the disease, the spread of antimicrobial resistance, as well as their connection to the disorders of gut microbiota are shown. It is known that most pathogens of urinary infections originate from the gut microbiota, where they exist for a long time, forming reservoirs. The normal composition and functions of the microbiota prevent colonization of the intestine by pathogenic bacteria and reduce the risk of developing this disease. Ways of correction through diet, probiotics, as well as fecal microbiota transplantation are considered. Modulation of gut microbiota may be a promising approach in the treatment and prevention of urinary tract infections. Meanwhile, a qualitative evidence base on the eectiveness of this strategy has not been formed. Further research in this direction is required.