Open AccessInvolvement of ATM/ATR-p38 MAPK cascade in MNNG induced G1-S arrest
Author(s) -
Keqing Zhu,
Zhang Suo-jiang
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i9.2073
Subject(s) - comet assay , dna damage , microbiology and biotechnology , mapk/erk pathway , p38 mitogen activated protein kinases , kinase , western blot , immunoprecipitation , chemistry , biology , antibody , biochemistry , dna , immunology , gene
To understand the effect of low concentration of N-methyl-N'-nitro-nitrosoguanidine (MNNG), which is a widely distributed environmental mutagen and carcinogen especially for human gastric cancer, on DNA damage and to study its possible pathway in regulating cell cycle arrest.