Open AccessPotential inhibition of cytochrome P450 3A4 by propofol in human primary hepatocytes
Author(s) -
Liqun Yang,
Wenyan Yu,
Yunfei Cao,
Bin Gong,
Qing Chang,
Guang Yang
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i9.1959
Subject(s) - cyp3a4 , cytochrome p450 , propofol , pharmacology , drug metabolism , isozyme , chemistry , metabolism , drug , biology , biochemistry , enzyme
Hepatic cytochrome P450 isoenzymes constitute a superfamily of hemoproteins that play a major role in the metabolism of endogenous compounds and in the detoxification of xenobiotic molecules. P450 3A4 is one of the most important forms in human being, and mediates the metabolism of around 70 % of therapeutic drugs and endogenous compounds. Propofol, a widely used intravenous anesthetic drug, is known to inhibit cytochrome P450 activities in isolated rat hepatocytes. The goal of this study was to evaluate the potential efficacy of propofol on P450 3A4 in a dose-dependent manner to understand its drug-drug interaction.