Open AccessInfluence of acute hyperglycemia in human sepsis on inflammatory cytokine and counterregulatory hormone concentrations
Author(s) -
Wenkui Yu,
Weiqin Li,
Ning Li,
Jieshou Li
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i8.1824
Subject(s) - medicine , endocrinology , glucagon , insulin , basal (medicine) , radioimmunoassay , impaired glucose tolerance , sepsis , hormone , insulin resistance
In human sepsis, a prominent component of the hypermetabolite is impaired glucose tolerance (IGT) and hyperglycemia. Elevations in plasma glucose concentration impair immune function by altering cytokine production from macrophages. We assessed the role of glucose in the regulation of circulating levels of insulin, glucagon, cortisol, IL-6 and TNF-alpha in human sepsis with normal or impaired glucose tolerance.