Open AccessGeneration of cytotoxic T cell against HBcAg using retrovirally transduced dendritic cells
Author(s) -
ChuanFan Ding,
Kun Yao,
Tiantai Zhang,
Feng Zhou,
Lin Xu,
Jiang-ying Xu
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i7.1512
Subject(s) - hbcag , viral vector , microbiology and biotechnology , cytotoxic t cell , biology , virology , transfection , hepatitis b virus , recombinant dna , cell culture , virus , in vitro , gene , biochemistry , genetics , hbsag
Cytotoxic T lymphocytes (CTLs) play an important role in resolving HBV infection. In the present study, we attempted to evaluate the efficiency of bone marrow-derived dendritic cells (DCs) transduced with recombinant retroviral vector bearing hepatitis B virus (HBV) core gene and the capability of generating CTLs against HBcAg by genetically modified DCs in vivo.