Open AccessRapid detection of the known SNPs of CYP2C9 using oligonucleotide microarray
Author(s) -
Siyuan Wen
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i6.1342
Subject(s) - genotyping , single nucleotide polymorphism , biology , cyp2c9 , allele , genotype , microbiology and biotechnology , genetics , gene
Cytochrome P450 2C9 (CYP2C9) is a polymorphic enzyme responsible for the metabolism of a large number of clinically important drugs. Individuals with mutant enzymes may risk serious side effects under routine therapy with certain drugs metabolized by CYP2C9. In order to facilitate the detection of the known SNPs of CYP2C9, an allele-specific oligonucleotide (ASO) based microarray was made.