Rapid mitogen-activated protein kinase by basic fibroblast growth factor in rat intestine after ischemia/reperfusion injury | Zendy

Xiaobing Fu | Zendy

Open Access

Rapid mitogen-activated protein kinase by basic fibroblast growth factor in rat intestine after ischemia/reperfusion injury

Author(s) -

Xiaobing Fu

Publication year - 2003

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.v9.i6.1312

Subject(s) - basic fibroblast growth factor , reperfusion injury , mapk/erk pathway , superior mesenteric artery , protein kinase a , medicine , ischemia , endocrinology , kinase , mitogen activated protein kinase , p38 mitogen activated protein kinases , biology , growth factor , biochemistry , receptor

Previous studies showed that exogenous basic fibroblast growth factor (bFGF or FGF-2) could improve physiological dysfunction after intestinal ischemia/ reperfusion (I/R) injury. However, the mechanisms of this protective effect of bFGF are still unclear. The present study was to detect the effect of bFGF on the activities of mitogen-activated protein kinase (MAPK) signaling pathway in rat intestine after I/R injury, and to investigate the protective mechanisms of bFGF on intestinal ischemia injury.

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