Open AccessCyclooxygenase-2 expression and angiogenesis in colorectal cancer
Author(s) -
Bin Xiong,
Taojiao Sun,
Huipin Yuan,
Ming-Bo Hu,
Weidong Hu,
Fu-Lin Cheng
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i6.1237
Subject(s) - angiogenesis , cyclooxygenase , colorectal cancer , medicine , metastasis , vascular endothelial growth factor , cancer , immunohistochemistry , cancer research , pathology , biology , vegf receptors , biochemistry , enzyme
Cyclooxygenase-2 is involved in a variety of important cellular functions, including cell growth and differentiation, cancer cell motility and invasion, angiogenesis and immune function. However, the role of cyclooxygenase-2 as an angiogenic factor in colorectal cancer tissue is still unclear. We investigated the relationship between cyclooxygenase-2 and angiogenesis by analyzing the expression of cyclooxygenase-2 in colorectal cancer tissue, as well as its association with vascular endothelial growth factor (VEGF) and microvascular density (MVD).