Open AccessPPARγ pathway activation results in apoptosis and COX-2 inhibition in HepG2 cells
Author(s) -
Mingyi Li
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i6.1220
Subject(s) - troglitazone , apoptosis , microbiology and biotechnology , cell growth , cell culture , biology , peroxisome proliferator activated receptor , blot , signal transduction , receptor , programmed cell death , chemistry , biochemistry , gene , genetics
To investigate whether troglitazone (TGZ), the peroxisome proliferator-activated receptor (PPAR) gamma ligand, can induce apoptosis and inhibit cell proliferation in human liver cancer cell line HepG2 and to explore the molecular mechanisms.