Open AccessRepression of allo-cell transplant rejection through CIITA ribonuclease P+hepatocyte
Author(s) -
Rong Guo,
Ping Zou,
Huimin Fan,
Feng Gao,
Qingxin Shang,
Yuan-Ning Cao,
Haixia Lü
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i5.1077
Subject(s) - ciita , microbiology and biotechnology , biology , rna , mhc class ii , chemistry , major histocompatibility complex , gene , biochemistry
Allo-cell transplant rejection and autoimmune responses were associated with the presence of class II major histocompatibility complex (MHC II) molecules on cells. This paper studied the effect of Ribonuclease P (RNase P) against CIITA, which was a major regulator of MHCII molecules, on repressing the expression of MHCII molecules on hepatocyte.