Open AccessPleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase
Author(s) -
Xinglong Yang,
Yali Zhang,
Zhuo-Sheng Lai,
Feiyue Xing,
Liu Yu-hu
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i4.800
Subject(s) - pleckstrin homology domain , protein kinase c , fusion protein , microbiology and biotechnology , c2 domain , immunoprecipitation , bruton's tyrosine kinase , biology , western blot , protein kinase domain , jurkat cells , tyrosine kinase , biochemistry , kinase , signal transduction , t cell , gene , recombinant dna , mutant , immune system , membrane , immunology
To study the detail mechanism of interaction between PKC and GRK(2) and the effect of GRK(2) on activity of PKC.