Open AccessConstruction, expression and tumor targeting of a single-chain Fv against human colorectal carcinoma
Author(s) -
Fang Jin,
Haiming Jin,
Jin-Dan Song
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i4.726
Subject(s) - biodistribution , monoclonal antibody , microbiology and biotechnology , in vivo , pharmacokinetics , recombinant dna , antibody , chemistry , carcinoma , cancer research , biology , medicine , gene , pathology , immunology , pharmacology , biochemistry
A single-chain antibody fragment, ND-1scFv, against human colorectal carcinoma was constructed and expressed in E.coli, and its biodistribution and pharmacokinetic properties were studied in mice bearing tumor.