Open AccessThe microcell mediated transfer of human chromosome 8 into highly metastatic rat liver cancer cell line C5F
Author(s) -
Hu Liu,
ShengLong Ye,
Jiong Yang,
ZhaoYou Tang,
Yinkun Liu,
LunXiu Qin,
Shuang–Jian Qiu,
Ruixia Sun
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i3.449
Subject(s) - biology , chromosome , microbiology and biotechnology , cancer , metastasis , clone (java method) , cloning (programming) , genetics , cancer research , gene , computer science , programming language
Our previous research on the surgical samples of primary liver cancer with CGH showed that the loss of human chromosome 8p had correlation with the metastatic phenotype of liver cancer. In order to seek the functional evidence that there could be a metastatsis suppressor gene(s) for liver cancer on human chromosome 8, we tried to transfer normal human chromosome 8 into rat liver cancer cell line C5F, which had high metastatic potential to lung.