Open AccessProtective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress
Author(s) -
Cláudia Pinto Marques Souza de Oliveira,
P Kassab,
Fábio Pinatel Lopasso,
Heraldo Possolo de Souza,
Mariano Janiszewski,
Francisco Rafael Martins Laurindo,
K Iriya,
Antônio Atílio Laudanna
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i3.446
Subject(s) - oxidative stress , ascorbic acid , adenocarcinoma , cancer , gastric mucosa , reactive oxygen species , pathology , medicine , h&e stain , staining , vitamin c , carcinogenesis , gastroenterology , stomach , chemistry , biochemistry , food science
Oxidative stress participates in the cell carcinogenesis by inducing DNA mutations. Our aim was to assess whether ascorbic acid, an antioxidant, could have a role in preventing ROS (Reactive Oxygen Species) generation in experimental gastric carcinoma in a rat model.