Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases | Zendy

Liqun Yang | Zendy

Open Access

Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases

Author(s) -

Liqun Yang

Publication year - 2003

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.v9.i2.359

Subject(s) - cirrhosis , cyp3a4 , medicine , blot , isozyme , cytochrome p450 , gastroenterology , gene expression , northern blot , biliary cirrhosis , biology , jaundice , cyp3a5 , endocrinology , gene , enzyme , metabolism , biochemistry , genotype , disease , autoimmune disease

To determine whether parenchymal cells or hepatic cytochrome P450 protein was changed in chronic liver diseases, and to compare the difference of CYP3A4 enzyme and its gene expression between patients with hepatic cirrhosis and obstructive jaundice, and to investigate the pharmacologic significance behind this difference.

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