Open AccessDifferent alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases
Author(s) -
Linqi Yang,
Shen-Jing Li,
Yukun Cao,
Xiao-hua Man,
Weifeng Yu,
Hongyang Wang,
Mengchao Wu
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i2.359
Subject(s) - cirrhosis , cyp3a4 , medicine , blot , isozyme , cytochrome p450 , gastroenterology , gene expression , northern blot , biliary cirrhosis , biology , jaundice , cyp3a5 , endocrinology , gene , enzyme , metabolism , biochemistry , genotype , disease , autoimmune disease
To determine whether parenchymal cells or hepatic cytochrome P450 protein was changed in chronic liver diseases, and to compare the difference of CYP3A4 enzyme and its gene expression between patients with hepatic cirrhosis and obstructive jaundice, and to investigate the pharmacologic significance behind this difference.