Open AccessImpact of endoscopically minimal involvement on IL-8 mRNA expression in esophageal mucosa of patients with non-erosive reflux disease
Author(s) -
Yusei Kanazawa,
Hajime Isomoto,
Chun Yang Wen,
Aiping Wang,
Vladimir Saenko,
Akira Ohtsuru,
Fuminao Takeshima,
Katsuhisa Omagari,
Yohei Mizuta,
Ikuo Murata,
Shunichi Yamashita,
Shigeru Kohno
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i12.2801
Subject(s) - nerd , esophagus , reflux , gastroenterology , medicine , pathogenesis , gerd , asymptomatic , esophageal disease , pathology , biopsy , real time polymerase chain reaction , esophagitis , reverse transcription polymerase chain reaction , messenger rna , disease , biology , gene , biochemistry
Little has been known about the pathogenesis of non-erosive reflux disease (NERD). Recent studies have implicated interleukin 8 (IL-8) in the development and progression of gastroesophogeal reflux disease (GERD). The purpose of this study was to determine IL-8 RNA expression levels in NERD patients with or without subtle mucosal changes.