Open AccessAlterations of intestinal mucosa structure and barrier function following traumatic brain injury in rats
Author(s) -
Chun-Hua Hang,
Jinjie Shi,
Jieshou Li,
Wei Wu,
Hui Yin
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i12.2776
Subject(s) - intestinal mucosa , traumatic brain injury , pathology , lamina propria , barrier function , medicine , tight junction , intestinal permeability , edema , biology , epithelium , psychiatry , microbiology and biotechnology
Gastrointestinal dysfunction is a common complication in patients with traumatic brain injury (TBI). However, the effect of traumatic brain injury on intestinal mucosa has not been studied previously. The aim of the current study was to explore the alterations of intestinal mucosa morphology and barrier function, and to determine how rapidly the impairment of gut barrier function occurs and how long it persists following traumatic brain injury.