Open AccessEffect of NF-κB and p38 MAPK in activated monocytes/macrophages on pro-inflammatory cytokines of rats with acute pancreatitis
Author(s) -
Hongshan Liu,
Cheng Pan,
Qingguang Liu,
Wenli Yang,
Xuemin Liu
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i11.2513
Subject(s) - proinflammatory cytokine , acute pancreatitis , medicine , p38 mitogen activated protein kinases , tumor necrosis factor alpha , pancreatitis , endocrinology , mapk/erk pathway , monocyte , cytokine , inflammation , kinase , chemistry , biochemistry
Proinflammatory cytokines TNF-alpha and IL-6 play a main role in acute pancreatitis (AP). Cytokine biosynthesis runs through two major signaling pathways at the level of proteins: nuclear transcription factor-kappaB (NF-kappaB) and p38 mitogen-activated protein kinase (p38 MAPK). The aim of the study was to investigate the effect of NF-kappaB and p38 MAPK in activated monocytes/macrophages on cytokines of rats with acute pancreastitis.