Open AccessGut in diseases: Physiological elements and their clinical significance
Author(s) -
Lian-An Ding,
Jieshou Li
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i11.2385
Subject(s) - barrier function , bacterial translocation , pathophysiology , medicine , gastrointestinal tract , biology , chromosomal translocation , pathology , microbiology and biotechnology , biochemistry , gene
The intestinal barrier function of GI tract is very important in the body except for the function of digestion and absorption. The functional status of gut barrier basically reflects the stress severity when body suffers from trauma and various stimulations. Many harmful factors such as drugs, illnesses, trauma and burns can damage the gut barrier, which can lead to the barrier dysfunction and bacterial/endotoxin translocation. The paper discusses and reviews the concepts, anatomy, pathophysiology of gut barrier and its clinical relations.