Open AccessAdrenomedullin in cirrhotic and non-cirrhotic portal hypertension
Author(s) -
Veysel Tahan,
Erol Avşar,
Çetin Karaca,
Ezel Uslu,
Fatih Eren,
Seval Aydın,
H Uzun,
HO Hamzaoglu,
Fatih Beşışık,
Cem Kalaycı,
Atilla Ökten,
Nurdan Tözün
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i10.2325
Subject(s) - adrenomedullin , portal hypertension , medicine , cirrhosis , gastroenterology , portal venous pressure , hyperdynamic circulation , nitric oxide , vasodilation , endocrinology , receptor
Adrenomedullin (ADM) is a potent vasodilator peptide. ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown. plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.