Open AccessExpression of E-cadherin and β-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival
Author(s) -
Yongning Zhou
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i6.987
Subject(s) - intestinal metaplasia , pathology , dysplasia , atrophic gastritis , cadherin , catenin , immunohistochemistry , lymph node , signet ring cell , adenocarcinoma , carcinoma , signet ring cell carcinoma , biopsy , metaplasia , staining , beta catenin , medicine , biology , gastritis , cancer , gastroenterology , stomach , cell , gene , wnt signaling pathway , biochemistry , genetics
The E-cadherin-catenin complex is important for cell-cell adhesion of epithelial cells. Impairment of one or more components of this complex is associated with poor differentiation and increased invasiveness of carcinomas. We evaluated the expression pattern of E-cadherin and beta-catenin in gastric carcinoma and dysplasia and analyzed their relationship with tumor clinicopathological features and patient survival.