Open Accessp73β inhibits transcriptional activities of enhancer I and X promoter in hepatitis B virus more efficiently than p73α
Author(s) -
Zhenhua Xu,
Ming Zhao,
Tsaiping Li
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i6.1094
Subject(s) - enhancer , hbeag , hbsag , hepatitis b virus , hepatitis b virus pre beta , microbiology and biotechnology , biology , transcription (linguistics) , transfection , luciferase , virology , promoter , virus , enhancer rnas , gene , transcription factor , gene expression , hepatitis b virus dna polymerase , genetics , linguistics , philosophy
p73, as a novel member of a family of p53-related transcription factors, shares redundant functions with p53, such as the abilities of inducing apoptosis and suppressing growth. It is well known that p53 can repress HBV expression and transcription efficiently. The aim of this paper is to investigate the transcriptional effect of p73alpha and p73beta on hepatitis B virus (HBV) and to understand the correlation between HBV and p73.