Open AccessActivation of JNK by TPA promotes apoptosis via PKC pathway in gastric cancer cells
Author(s) -
Yan Chen,
Qiao Wu,
Siyang Song,
WenJin Su
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i6.1014
Subject(s) - apoptosis , wortmannin , microbiology and biotechnology , transfection , dapi , protein kinase c , signal transduction , biology , cancer cell , activator (genetics) , kinase , chemistry , cell culture , pi3k/akt/mtor pathway , cancer , biochemistry , genetics , gene
JNK cascade plays an important role in cell proliferation, differentiation and apoptosis. However, the exact function of JNK cascade for apoptosis induction remains largely unknown. In this study, the role of JNK activation stimulated by TPA in the process of apoptosis induction and its signaling transduction pathway in gastric cancer cells were investigated and determined.