Open AccessThe pre-synaptic blocker toosendanin does not inhibit secretion in exocrine cells
Author(s) -
Zong-Jie Cui,
Xiaotian He
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i5.918
Subject(s) - cholecystokinin , extracellular , calcium , secretion , stimulation , endocrinology , medicine , inhibitory postsynaptic potential , amylase , chemistry , calcium in biology , intracellular , collagenase , biology , receptor , biochemistry , enzyme
Toosendanin is a pre-synaptic blocker at the neuromuscular junction and its inhibitory effect is divided into an initial facilitative/stimulatory phase followed by a prolonged inhibitory phase. The present study investigated whether the subsequent inhibitory phase was due to exhaustion of the secretory machinery as a result of extensive stimulation during the initial facilitative phase. More specifically, this paper examined whether toosendanin could directly inhibit the secretory machinery in exocrine cells.